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Cover Articles

Books and Reviews


2017

133. Pitek A.S., Wang Y., Gulati S., Gao H., Stewart P.L., Simon D.I., Steinmetz NF. Elongated plant virus-based nanoparticles for enhanced delivery of thrombolytic therapies. Mol Pharm. 2017 Sep 7. doi: 10.1021/acs.molpharmaceut.7b00559. 

132. Lee P.W., Shukla S., Wallat J.D., Danda C., Steinmetz N.F., Maia J., Pokorski J.K. (2017) Biodegradable Viral Nanoparticle/Polymer Implants Prepared via Melt-Processing. ACS Nano. 2017 Sep 13. doi: 10.1021/acsnano.7b02786. 

131. Franke C.E., Czapar A.E., Patel R.B., Steinmetz N.F. (2017) Tobacco Mosaic Virus-Delivered Cisplatin Restores Efficacy in Platinum-Resistant Ovarian Cancer Cells. Mol Pharm. 2017 Sep 19. doi: 10.1021/acs.molpharmaceut.7b00466. 

130. Steinmetz N.F. (2017) Enter the Nanoman | In the Classroom, Nature Nanotechnology, 12, p. 928.

129.  Hu H., Zhang Y., Shuka S., Gu Y. Yu X. Steinmetz N.F. (2017), Dysprosium-Modified Tobacco Mosaic Virus 
Nanoparticles forUltra-High-Field Magnetic 
Resonance and Near-Infrared Fluorescence 
Imaging ofProstate Cancer. ACS Nano. DOI: 10.1021/acsnano.7b04472

128. Anderson C.E., Donnola S.B., Jiang Y., Batesole, Y., Darrah R., Drumm M., Brady-Kalnay S.M., Steinmetz N.F., Yu X., Griswold M.A., Flask C.A. (2017) Dual Contrast - Magnetic Resonance Fingerprinting (DC-MRF): A Platform for Simultaneous Quantification of Multiple MRI Contrast Agents. Scientific Reports: 7: 8431. DOI:10.1038/s41598-017-08762-9 

127. Cho C.-F., Yu L., Nsiasama T.K., Kadam A.N., Raturi A., Shukla S., Amadei G.A., Steinmetz N.F., Luyt L.G., Lewis J.D. (2017) Viral nanoparticles decorated with novel EGFL7ligands enable intravital imaging of tumorneovasculature. Nanoscale, DOI: 10.1039/c7nr02558k.

126. Veliz F.A., Ma Y., Molugu S.K., Tiu B.D.B., Stewart P.L., French R.H., Steinmetz N.F. (2017) Photon management throughvirus-programmed supramolecular arrays. Advanced Biosystems, in press.

125. Lam P.L., Steinmetz N.F. (2017) Plant viral and bacteriophage delivery of nucleic acid therapeutics. WIREs Nanomed Nanobiotechnol 2017, e1487. doi: 10.1002/wnan.1487. 

124. Kernan D.L., Wen A.M., Pitek A.S., Steinmetz N.F. (2017) Delivery of chemotherapeutic vcMMAE using tobacco mosaicvirus nanoparticles, Experimental Biology and Medicine, DOI: 10.1177/1535370217719222.

123. Le D.H.T., He Hu, Commandeur U., Steinmetz N.F. (2017) Chemical addressability of potato virus X for its applications in bio/nanotechnology, Journal of Structural Biology, doi:10.1016/j.jsb.2017.06.006

122. Lee K.L.*, Murray A.A.*, Le, D.H.T., Sheen M. R., Shukla S., Commandeur U., Fiering S., Steinmetz N.F. (2017) Combination of Plant Virus Nanoparticle-Based in Situ Vaccination with Chemotherapy Potentiates Antitumor Response. Nano Letters, 17, 4019-4028.
  *these authors contributed equally.

121. Poudel L., Twarock R., Steinmetz N.F., Podgornik R., Ching, W.-Y. (2017) Impact of Hydrogen Bonding in Binding Site Between Capsid Protein and MS2 Bacteriophage ssRNA. The Journal of Physical Chemistry B, 121, 6321-6330. 

120. Wallat J.D., Wek K., Chariou P.L., Carpenter B.L., Ghiladi R.A., Steinmetz N.F., Pokorski J.K. (2017) Fluorinated polymer–photosensitizer conjugates enable improved generation of ROS for anticancer photodynamic therapy. Polymer Chemistry. 8, 3195-3202. 

119. Czapar A.E., Steinmetz N.F. (2017) Plant viruses and bacteriophages for drug deliveryin medicine and biotechnology. Current Opinion in Chemical Biology 38:1-9.

118. Hoopes P.J., Mazur C.M., Osterberg B., Song A., Gladstone D.J., Steinmetz N.F., Veliz F.A., Bursey A.A. Wagner R.J., Fiering S.N. (2017) Effect of intra-tumoral magnetic nanoparticle hyperthermia and viral nanoparticle immunogenicity on primary and metastatic cancer. Proc. SPIE. 10066, Energy-based Treatment of Tissue and Assessment IX, 100660G. (February 24, 2017) doi: 10.1117/12.2256062

117. Hoopes P.J., Moddie K.L., Petryk A.A., Petryk J.D., Sechrist S., Gladstone D.J., Steinmetz N.F., Veliz F.A., Bursey A.A., Wagner J.W., Rajan A., Dugat D., Crary-Burney M., Fiering S.N. (2017) Hypo-fractionated radiation, magnetic nanoparticle hyperthermia and viral immunotherapy treatment to spontaneous canine cancer. Proc. SPIE. 10066, Energy-based Treatment of Tissue and Assessment IX, 100660G. (February 24, 2017). doi: 10.1117/12.2256213 

116. Chariou P.L., Steinmetz N.F. (2017) Delivery of Pesticides to Plant Parasitic Nematodes Using Tobacco Mild Green Mosaic Virus as a Nanocarrier. ACS Nano 11, 4719-4730.

115. Lam P., Keri R.A., Steinmetz N.F. (2017) A Bioengineered Positive Control for Rapid Detection of the Ebola 2 Virus by Reverse Transcription Loop-Mediated Isothermal 3 Amplification (RT-LAMP), ACS Biomaterials Science and Engineering, 3, 452-459.

114. Le D.H.T*, Lee K.L.*, Shukla S., Commandeur U., Steinmetz N.F., (2017) Potato virus X, a filamentous plant viral nanoparticle for doxorubicin delivery in cancer therapy, Nanoscale, 9, 2348-2357. *These authors contributed equally.

113. Lee P.W., Isarov S.A., Wallt J.D., Molugu S.K., Shukla S.*, Sun J.E.P., Zhang J., Zheng Y., Dougherty M.L., Konkolewicz D., StewartP.L., Steinmetz N.F., Hore M.J.A.,Pokorski J.K. (2017) Polymer Structure and Conformation Alterthe Antigenicity of Virus-like Particle−Polymer Conjugates , J. Am. Chem. Soc. 139:3312-3315.

112. Pitek, A.S.,Veliz, F.A., Jameson, S.A., Steinmetz,N.F. (2017) Interactions between plant viral nanoparticles and blood plasma proteins, and their impact on the VNP in vivo fates, Methods in Molecular Biology, in press.

111. Bruckman, M.A.,Czapar, A.E., Steinmetz N.F. (2017) Drug-loaded plant-virus based nanoparticles for cancer drug delivery, Methods in Molecular Biology, in press.

110. Tiu B.D.B., Advicula R.C., Steinmetz N.F. (2017) Nanomanufacture of Free-standing, Porous, Janus-TypeFilms of Polymer-Plant Virus Nanoparticle Arrays, Methods in Molecular Biology, in press.

109. Shukla S., Dickmeis C., Fischer R., Commandeur U., Steinmetz N.F. (2017) In planta Production of Fluorescent Plant Virus-based Nanoparticles, Methods in Molecular Biology, in press.

108. Gulati N.M., Pitek A.S., Steinmetz N.F.#, Stewart P.L.# (2017) Cryo-Electron Tomography Investigation of Camouflaged Tobacco Mosaic Virus Nanoparticles, Nanoscale. 9, 3408-3415. #co-corresponding authors **Cover article.

107. Tiu, B.D.B., Kernan, D.L., Tiu, S.B., Wen, A.M., Zheng Y., Pokorski, J.K., Advincula, R.C., Steinmetz, N.F. (2017) Electrostatic layer-by-layer construction of fibrous TMV biofilms, Nanoscale, 9, 1580-1590.

106. Wallat J.D., Czapar A.E., Wang C., Wen A.M., Yu X., Steinmetz N.F., Pokorski J.K. (2017) Optical and Magnetic Resonance Imaging by Fluorous Colloidal Nanoparticles, Biomacromolecules, 18:103-112.

105. Shukla S., Myers J.T., Woods S.E., Gong X., Czapar A.E., Huang A.Y., Commandeur U., Levine A., Steinmetz N.F. (2017) Plant virus-based HER2 vaccines: Immune response driven by transport, localization and cellular interactions of CPMV and PVX carriers, Biomaterials, 121:15-27.

104. Bludau H.*, Czapar A.E.*, Pitek A.S., Shukla S., Jordan R., Steinmetz N.F. (2017) POxylation as an alternative stealth coating for biomedical applications, European Polymer Journal, 88, 679-688.  *these authors contributed equally.

103. Glidden, M.D., Edelbrock, J.F., Wen, A.M., Shukla, S., Ma, Y., French, R.H., Pokorski, J.K., Steinmetz, N.F. (2017) Application of viral nanoparticles in materials and medicine, in Chemoselective and Bioorthogonal Ligation Reactions: Concepts and Applications, Wiley-VCH.

2016

102. Steinmetz, N.F. (2016) Viral nanoparticles as platforms for next generation therapeutics and imagingdevices. In Nanomedicine in Cancer, Edited by LP Balogh, Pan Stanford Publishing. 

101. Sreekanth K.V., Alapan Y., ElKabbash M., Wen A.M., Ilker E., Hinczewski M., Gurkan U.A., Steinmetz N.F., Strangi G. (2016) Enhancing the Angular Sensitivity of Plasmonic Sensors Using Hyperbolic Metamaterials. Advanced Optical Materials, 4, 1767-1772.

100. Poudel L., Steinmetz N.F., French R.H., Parsegian V.A., Podgornik R. and Ching W.Y. (2016). Implication of the solvent effect, metal ions andtopology in the electronic structure and hydrogenbonding of human telomeric G-quadruplex DNA. Physical Chemistry and Chemical Physics, 18:21573-21585.

99. Tiu BDB, Tiu SB, Wen AM,Lam P, Steinmetz NF, Advincula RC (2016) Free-standing, Nanopatterned Janus Membranes of Conducting Polymer-VirusNanoparticle Arrays, Langmuir, 32, 6185-6193.

98. Yasar S, Schimelman JB, Aksoyoglu MA, Steinmetz NF, French RH, Parsegian VA, Podgornik R (2016) X-ray characterization of mesophases of human telomeric G-quadruplexes and other DNA analogues. Scientific Reports, 6, 27079.

97. Wen, AM and Steinmetz NF (2016) Design of virus-based nanomaterials for medicine,biotechnology, and energy. Chem Soc Rev, 45, 4074-4126. 

96. Shukla S, Steinmetz NF (2016) Emerging nanotechnologies for cancer immunotherapy. Experimental Biology and Medicine, 241, 1116-1126.

95. Wen AM, Lee KL, Cao PF, Pangilinan K, Carpenter BL, Lam P, Veliz F, Ghiladi RA, Advincula RC,Steinmetz NF. (2016) Utilizing viral nanoparticle/dendron hybrid conjugates in photodynamic therapy for dual delivery to macrophages and cancer cells. Bioconjug Chem. 27, 1227-1235. 

94. Chariou PL, Lee KL, Pokorski JK, Saidel GM, Steinmetz NF. (2016): Diffusion and Uptake of Tobacco Mosaic Virus as Therapeutic Carrier in Tumor Tissue: Effect of Nanoparticle Aspect Ratio. J Phys Chem B. 120, 6120-6129.

93. Shukla S, Dorand RD, Meyers JT, Woods SE, Gulati NM, Stewart PL, Commandeur U, Huang A, Steinmetz NF (2016): Multiple Administrations of Viral Nanoparticles Alter in vivo Behavior – Insights from Intravital Microscopy, ACS Biomater. Sci. Eng., 2, 829-837.

92. Lee, K. L., Carpenter, B. L., Amy M. Wen, Ghiladi R. A., Steinmetz, N. F. (2016) High-aspect ratio nanotubes formed by tobacco mosaic virus for delivery of photodynamic agents targeting melanoma, ACS Biomater. Sci. Eng., 2, 838-844.

91. Lam, P., Gulati N. M., Stewart, P. L., Keri R. A., Steinmetz, N. F. (2016)  Bioengineering of Tobacco Mosaic Virus to Create a Non-InfectiousPositive Control for Ebola Diagnostic Assays. Sci. Rep. 6, 23803.

90. Czapar, A. E., Zheng, Y.-R., Riddell, I. A., Shukla, S., Awuah, S. G., Lippard, S. J., & Steinmetz, N. F. (2016). Tobacco mosaic virus delivery of phenanthriplatin for cancer therapy. ACS Nano, 10, 4119-4126.

89. Ganguly R, Wen AM, Myer AB, Czech T, Sahu S, Steinmetz NF, Raman P (2016) Anti-atherogenic effect of trivalent chromium-loaded CPMV nanoparticles in human aortic smooth muscle cells under hyperglycemic conditions in vitro. Nanoscale, 8, 6541-6554.

88. Bruckman MA, Czapar AE, VanMeter A, Randolph LN, Steinmetz NF (2016) Tobacco mosaic virus-based protein nanoparticles and nanorods for chemotherapy delivery targeting breast cancer. Journal of Controlled Release, 213, 103-113.

87. Pitek AS, Jameson SA, Veliz FA, Shukla S, Steinmetz NF (2016) Serum Albumin “Camouflage” of Plant Virus Based Nanoparticles Prevents Their Antibody Recognition and Enhances Pharmacokinetics. Biomaterials, 89, 89-97.

86. Eifler J, Podgornik R, Steinmetz NF, French RH, Parsegian VA, Ching W-Y (2016) Charge Distribution and Hydrogen Bonding of a Collagen a2-Chain in Vacuum, Hydrated, Neutral, and Charged Structural Models. International Journal of Quantum Chemistry, 116, 681-691. 

85. Pitek AS, Wen AM, Shukla S, Steinmetz NF (2016) The protein corona of plant virus nanoparticles influences their dispersion properties, cellular interactions, and in vivo fates. Small, 12, 1758-1769.

84. Lee KL, Twyman RM, Fiering S, Steinmetz NF (2016) Virus-based nanoparticles as platform technologies for modern vaccines. Wiley Interdiscip Rev Nanomed Nanobiotechnol, 8, 554-578.

83. Czapar, A.E.*, Steinmetz, N.F. (2016) Paving the way toward translational application of virus-based nanoparticles; in Nanomaterials in Pharmacology (Eds. ZR Lu, Sakuma), Methods in Pharmacology and Toxicology, Springer.

82. Lizotte, H, Wen, A.M., Sheen, M.R., Fields, J., Rojanasopondist, P., Steinmetz, N.F.#, Fiering, S.#
 (2016) In situvaccination with cowpea mosaic virus nanoparticles suppresses metastatic cancer. Nature Nanotechnology, 11, 295-303. #co-corresponding authors.

2015

81.    Wen, A.W.*, Le, N., Zhou, X., Steinmetz, N.F.#, Popkin, D.L.# (2015) Tropism of CPMV toProfessional Antigen Presenting Cells Enables
 a Platform to Eliminate ChronicInfections. ACS Biomaterials Sci Eng, 1,1050-1054. # co-corresponding authors.

80.  Bruckman, M.A.*, Randolph, L.N.*, Gulati, N.G.*, Stewart, P.L., Steinmetz, N.F. (2015) Silica-coated Gd(DOTA)-loaded protein nanoparticles enable magnetic resonance imaging of macrophages, J. Mater. Chem. B., 3, 7503-7510. **Cover article.

79.  Uhde-Holzem, K., McBurney, M.*, Tiu, B.D.*, Advincula, R.C., Fischer, R., Commandeur U., Steinmetz N.F. (2015) .Production of immunosorbent nanoparticles by displaying single-domain protein A on potato virus X, Macromol. Biosci., 16, 231-241.

78.  Koudelka, K. J., Pitek, A.*, Manchester, M., Steinmetz, N.F. (2015) Virus-based nanoparticles as versatile nanomachines, Annu. Rev. Virol. 2015. 2:27.1–27.23

77.  Worden, M., Bruckman, M.A.*, Kim, M.-H., Steinmetz, N.F., Kikkawa, J.M., LaSpina C., Hegmann, T. (2015) Aqueous synthesis of polyhedral ‘‘brick-like’’ iron oxide nanoparticles for hyperthermia and T2 MRI contrast enhancement, J. Mater. Chem. B., 3, 6877-6868.

76.  Au, L., Meisch, J.P., Das, L.M., Binko, A.M., Boxer, R.S., Wen, A. M.*, Steinmetz, N.F., Lu, K.Q. (2015) Suppression of hyperactive immune responses protects against nitrogen mustard injury. Journal of Investigative Dermatology, 135, 2971-2981.

75.  Wen A.M.*, Wang Y., Jiang K., Hsu G.C.*, Gao H., Lee K.L.*,Yang A.C.*, Simon D.I., Steinmetz N.F.(2015) Shaping bio-inspired nanotechnologies to target thrombosis for dualoptical-magnetic resonance imaging, J Mater Chem B, 3, 6037-6045.

74.  Shukla S.* DiFranco N.A.*, Wen A.M.*, Commandeur U., Steinmetz N.F. (2015) To target or notto target: Active vs. Passive Tumor Homing of Filamentous Nanoparticles basedon Potato virus X. Cellular and Molecular Bioengineering, 8, 433-444.

73.  Lee K.L.*, Shukla S*, Wu M.*, Ayat N.R.*, El Sanadi C.E.,Wen A.M.*, Edelbrock J.F., Pokorski J.K., Commandeur U., Dubyak G.R., Steinmetz N.F. (2015) Stealth filaments: Polymer chain length andconformation affect the in vivo fate of PEGylated potato virus X. Acta Biomater. 19, 166-179..

72.  Chariou P.L.*, Lee K.L.*, Wen A.M.*, Gulati N.M.*,Stewart P.L., Steinmetz N.F. (2015) Detection and Imaging of Aggressive Cancer CellsUsing an Epidermal Growth Factor Receptor (EGFR)-Targeted Filamentous PlantVirus-Based Nanoparticle. Bioconjug Chem. 201526(2):262-9.

71.  Dryden D.M., Hopkins J.C., Denoyer L.K., Poudel L., Steinmetz N.F., Ching W.Y.,Podgornik R., Parsegian A., French R.H. (2015) van der Waals Interactions on the Mesoscale:Open-Science Implementation, Anisotropy, Retardation, and Solvent Effects.Langmuir, 31, 10145-10153.

70.  Poudel L., Wen A.M.,* French R.H., Parsegian V.A.,Podgornik R., Steinmetz N.F.,Ching W.Y.. Electronic structure and partial charge distribution of doxorubicinin different molecular environments. ChemPhysChem. 16,1451-60.

69.     Wen A.M.*, Podgornik R.P., Strangi G., Steinmetz N.F. (2015) Photonics andplasmonics go viral: self-assembly of hierarchical metamaterials, RendicontiLincei, 2, 129-141.

68.     De Luca A., Bartolino R., Correa-Duarte M.A., Curri M.L.,Steinmetz N.F., Strangi G. (2015)Gain-Assisted Plasmonic Metamaterials: Mimicking Nature to go Across Scales.Rendiconti Lincei, 2, 161-174.

67.     Shukla S.* Eber F.J., Nagarajan A.S.*, DiFranco N.A.*,Schmidt N., Wen A.M.*, Eiben S., Twyman R.M., Wege C., Steinmetz N.F. (2015) The impact of aspect ratio on biodistributionand tumor homing of rigid soft-matter nanorods. Advanced Healthcare Materials, 4, 874-882.

66.     Shukla S.*, SteinmetzN.F. (2015) Virus-based nanomaterials as PET and MR contrast agents: fromtechnology development to translational medicine, WIRES Nanomedicine andNanobiotechnology, doi: 10.1002/wnan.1335, Epub2015 Feb 12.

65.     Wen A.M.*, Infusino M., De Luca A., Kernan D.L.*,Czapar A.E.*, Strangi G., Steinmetz N.F.,(2015) Interface of physics and biology: engineering virus-based nanoparticlesfor biophotonics. Bioconj. Chem., 26, 51-62.

64.     Bruckman M.A.*, VanMeter A.*, Steinmetz N.F. (2015) Nanomanufacturing of tobacco mosaicvirus-based spherical biomaterials using a continuous flow method. ACSBiomaterials Science and Engineering, 12,13-18.

63.     Schimelman J.B.*, Dryden D.M., Poudel L., Ching W.-Y.,Podgornik R., Parsegian V.A., Denoyer L.K., Steinmetz N.F., French R.H. (2015) Optical properties andelectronic transitions of DNA oligonucleotides as a function of composition andstacking sequence. Physical Chemistry and Chemical Physics, 17, 4589-4599.

62.    Ma Y., Acosta D.M., Whitney J.R.*, Podgornik R., SteinmetzN.F., French R.H., Parsegian V.A. (2015) Determination of the second virial coefficient of bovine serum albuminunder varying pH and ionic strength by composition-gradient multi-angle staticlight scattering. J Biol Phys. 41, 85-97.

61.    Rehor, I. Lee, K.L.*, Chen K.*, Hajek, M., Havlik, J., Lokajova, J., Masat, M., Slegerova, J., Shukla, S.*, Heidari, H., Bals, S., Steinmetz, N.F.#, Cigler, P.# (2015) Plasmonic Nanodiamonds: Targeted Core–Shell Type Nanoparticles for Cancer Cell Thermoablation. Adv Healthc Mater. 18, 460-8. #co-corresponding authors.

60. Steinmetz N.F., Manchester M. (2015) Viral Nanoparticles: Tools for Materials Science and Medicine. R. Bawa, G. Audette and I. Rubinstein. (Editors): Handbook of Clinical Nanomedicine, Pan Stanford Publishing, Singapore (2015), 2500+ pages, 2-volume set (in press) [Hardcover ISBN: 9789814316170; eBook ISBN: 9789814411660]

59. Wen A.M.*, Cho, C.-F., Lewis J.D., Steinmetz, N.F., (2015) The application of plant viral nanoparticles in tissue-specific imaging, in Nanotechnology in Biomedical Imaging, Wiley-VCH

2014

58.    Rehor, I., Slegerova, J., Kucka, J., Proks, V.,Petrakova, V., Adam, M.P., Treussart, F., Turner, S., Bals, S., Ledvina, L.Wen, A.M.*, Steinmetz, N.F., Cigler,P., (2014) Shape Normalization of Fluorescent Nanodiamonds by BiocompatibleTranslucent Shells, Small, 10, 1106-1115. *Cover article

57.    Bruckman M.A.*, RandolphL.*, van Meter A.*, Shoftstall A.J., Taurog, R.E., Steinmetz N.F. (2014) Biodistributionof rod-shaped and spherical tobacco mosaic virus in mice. Virology 449,163-173.

56.     Bruckman,M.A.*, Jiang, K., Simpson, E.J.,Randolph L., LuytL.G., Yu, X., Steinmetz, N.F. (2014) Dual-Modal Magnetic Resonance and Fluorescence Imaging of Atherosclerotic Plaques in Vivo Using VCAM-1 Targeted Tobacco Mosaic Virus. Nano Letters, 14, 1551-1558.

55. Lee, K.L.*, Uhde-Holzem K., Fischer, R., Commandeur, U., Steinmetz N.F. (2014) Genetic engineering and chemical modification of potato virus X. Virus hybrid as nanomaterials, Methods in Molecular Biology, 1108, 3-21.

54. Cho, C.-F., Sourabh, S.*, Simpson, E.S., Steinmetz, N.F., Luyt, L.G. and Lewis, J.D. (2014) Molecular targeted viral nanoparticles as tools for imaging cancer, Virus hybrid as nanomaterials, Methods in Molecular Biology, 1108, 211-230.

53. Bruckman, M.A.*, Steinmetz, N.F. (2014) Chemical Modification of the Inner and Outer Surfaces of Tobacco Mosaic Virus (TMV), Virus hybrid as nanomaterials, Methods in Molecular Biology, 1108, 173-185.

52.     Shukla, S.*, Dickmeis,C., Nagarajan, A.*, Fischer F., Commandeur, U., Steinmetz. N.F. (2014) Molecular farming of fluorescent virus-basednanoparticles for optical imaging in plants, human cells, and mouse models,Biomaterials Science, 22, 784-797,Emerging Investigators Issue 

51.     Wen, A.M.*, Steinmetz N.F. (2014) The aspect ratioof nanoparticle assemblies and the spatial arrangement of ligands can beoptimized to enhance the targeting of cancer cells Advanced HealthcareMaterials, 3, 1739-1744.

50.     Adhikari P., Wen A.M.*,French R.H., Parsegian V.A., SteinmetzN.F., Podgornik R., Ching W.Y. (2014). Electronic structure, dieletricresponse, and surface charge distribution of PEG (1FUV). SciRep. doi: 10.1038/srep05605.

49.     Shukla, S.*, Wen, A.M.*,Commandeur, U., Steinmetz N.F.(2014) Presentation of HER2 epitopes using a filamentous plant virus-based vaccination platform, J. Materials Chemistry B, 2, 6249-6258.

48.           Shukla, S.*, Wen, A.M.*, Ayat, N.R.*, Commandeur, U., Gopalkrishnan R., Broome,A.-M., Lozada, K.,Keri, R.A., Steinmetz, N.F. (2014) Biodistribution and clearance of afilamentous plant virus in healthy and tumor-bearing mice. Nanomedicine 9,221-235. 

2013

47.     Bruckman, M.A.*, Yu, X. Steinmetz, N.F. (2014) Engineering Gd-loaded nanoparticles to enhance MRI sensitivity, Nanotechnology, 24, Number 26.

46.     Lee, K.L.*, Hubbard, L., Hern, S.*, Yildiz, I.*, Gratzl, M.G., Steinmetz, N.F. (2013) Shape matters: the diffusion rates of TMV rods and CPMV icosahedrons in a spheroid model of extracellular matrix are distinct, Biomaterials Science, 1, 581-588.

45.     Yildiz, I.*, Lee K.L.*, Chen, K.*, Steinmetz, N.F. (2013) Infusion of imaging and therapeutic molecules into the plant virus-based carrier cowpea mosaic virus: cargo-loading and in vitro delivery, Journal of Controlled Release 172, 568-578. 

44.     Bruckman, M.A.*, Jiang,K., Hern S.*, Flask, C., Yu, X., Steinmetz, N.F. (2013) Tobacco mosaicvirus rods and spheres as supramolecular high-relaxivity MRI contrast agents.Journal of Materials Chemistry B, 1, 1482-1490. 

43.     Wen, A.M.*, Rambhia, P.*, French, R.H., Steinmetz, N.F. (2013) Design rules for nanomedical engineering: from physical virology to the applications of virus-based materials in medicine. J of Biol Physics, 39m, 301-325.

42.     Shukla, S.*, Ablack, A.L., Wen, A.M.*, Lee, K.L.*, Lewis, J.D., Steinmetz, N.F. (2013) Increased tumor homing and tissue penetration of the filamentous plant viral nanoparticle potato virus X. Molecular Pharmaceutics, 10, 33-43.

41.     Aljabali, A.A.A.#, Shukla, S.#*, Lomonossoff, G.P., Steinmetz, N.F.#, Evans, D.J.# (2013) CPMV-DOX delivers. Molecular Pharmaceutics, 10, 3-10. #both authors contributed equally, #co-corresponding authors

40. Guest Editor: Steinmetz, N.F., Viral nanoparticles in drug delivery and imaging, Molecular Pharmaceutics, 2013, Special Issue. page 1ff.

2012

39.     Wen, A.M.*, Shukla, S.*, Saxena, P., Aljabali, A.A.A., Yildiz, I.*, Sourav, D.*, Mealy, J.*, Yang, A.*, Evans, D.J., Lomonossoff, G.P., Steinmetz, N.F. (2012) Interior engineering of a viral nanoparticle and its tumor homing properties, Biomacromolecules, 13, 3990-4001. 

38.     Aljabali, A.A.A., Barclay, J.E., Steinmetz, N.F., Lomonossoff, G.P., Evans, D.J. (2012) Controlled immobilisation of active enzymes on the cowpea mosaic virus capsid. Nanoscale, 4, 5640-5645.

37.     Wen, A.M.*, Ryan, M.J.*, Yang, A.C.*, Breitenkamp, K., Pokorski, J.K., Steinmetz N.F. (2012) Photodynamic activity of viral nanoparticles conjugated with C60. Chemical Communications, 48, 9044-9046.

36.     Hovlid M.L., Steinmetz, N.F., Laufer B., Lau J.L., Kuzelka, J., Wang, Q., Hyypia, T., Nemerow,G.R., Kessler, H., Manchester, M., Finn, M.G. (2012) Guiding Plant VirusParticles to Integrin-Displaying Cells. Nanoscale, 4, 3698-3705.

35.     Wen, A.M.*, Lee, K.L.*, Yildiz, I.*, Bruckman, M.A.*, Shukla, S.*, Steinmetz, N.F. (2012) Viral nanoparticles for in vivo tumor imaging. Journal of Visualized Experiments, e4352

34.     Wu, Z.*, Chen, K.*, Yildiz, I.*, Dirksen, A., Fischer, R. Dawson, P.E., Steinmetz, N.F. (2012) Development of viral nanoparticles for efficient intracellular delivery, Nanoscale, 4, 3698-3705. ** Cover article.

33.     Taghavian, O., Mandal, M.K., Steinmetz, N.F., Rasche, S., Spiegel, H., Fischer R., Schillberg, S. (2012) A potential nanobiotechnology platform based on infectious bursal disease subviral particles, RSC Advances, 2, 1970-1978.

32.     Yildiz, I.*, Tvestkova, I., Wen, A.W.*, Shukla, S.*, Masarapu, H., Dragnea, B., Steinmetz N.F. (2012) Engineering Brome mosaic virus for biomedical applications, RSC Advances, 2, 3670-3677.

31. Authors: Steinmetz, N.F. & Manchester, M. (2012) Viral Nanoparticles: Tools for Materials Science and Biomedicine. Pan Stanford Publishing, Singapore.

2011

30.     Steinmetz N.F., Maurer, J., Sheng H, Bensussan, A, Marcic, I., Kumar, V., Braciak, T. (2011) Two domains of vimentin are expressed on the surface of lymph node, bone and brain metastatic prostate cancer lines along with the putative stem cell marker proteins CD44 and CD133. Cancers, 3, 2870-2885.

29.     Steinmetz N.F., Ablack, A.L., Hickey J.H., Ablack J., Manocho, B., Mymryk, J.S., Luyt, L.G., Lewis, J.D., (2011) Intravital Imaging of Human Prostate Cancer Using Viral Nanoparticles Targeted to Gastrin-Releasing Peptide Receptors, Small, 20, 1664-1672. * Cover article

28.     Yildiz I.*, Shukla S.*, Steinmetz N.F., (2011) Applications of viral nanoparticles in medicine, Current Opinion in Biotechnology, 22, 901-908.

27. Steinmetz, N.F. (2011) Review of "Cancer Nanotechnology:Methods and Protocols (Methods in Molecular Biology)" BioMedicalEngineering OnLine 2010, 9:55, doi:10.1186

26.     Pokorski, J.K., Steinmetz,N.F. (2011): The Art of Engineering Viral Nanoparticles. MolecularPharmaceutics, 7, 29-43. *by invitation ** Top 10 article in Molecular Pharmaceutics in 2011

25.     Steinmetz N.F., Cho C.-F., Ablack, A., Lewis, J.D., Manchester, M. (2011): CPMV nanoparticles target surface vimentin on cancer cells. Nanomedicine, 6, 351-364.

24.     Huang, R.K.#, Steinmetz, N.F.#, Fu, C.-Y., Manchester, M. Johnson, J.E. (2011) Reprogramming bacteriophage HK97 to target and enter cancer cells. Nanomedicine, 6, 55-68. #both authors contributed equally

2010

23.     Steinmetz, N.F., Mertens, M.E., Taurog,R.E., Johnson, J.E., Commandeur, U., Fischer, R., Manchester, M. (2010) Potatovirus X as a novel platform for biomedical applications. Nano Letters, 10,305-312.

22.     Brunel, F.M., Lewis,J.D., Destito, G., Steinmetz, N.F., Manchester, M., Stuhlmann, H.,Dawson, P.E. (2010) Optical molecular imaging of tumors using PEGylatedfluorescent viral nanoparticles targeted to VEGF receptor 1.  Nano Letters, 10, 1093-1097.

21.     Steinmetz, N.F. (2010) Viralnanoparticles as platforms for next generation therapeutics and imagingdevices. Nanomedicine NBM, 6, 634-641.

20.     Leong, H.S., Steinmetz N.F., Ablack, A., Manchester, M., Lewis, J.D. (2010) Viral nanoparticles asa platform for intravital imaging of embryonic and tumour neovasculature.Nature Protocols, 5 (8), 1406-1417.

19.     Hong, V.#, Steinmetz, N.F.#, Manchester, M., Finn, M.G. (2010) Cu-catalyzed azide-akynecycloaddition reactions for live cell labeling. Bioconjugate Chemistry, 21, 1912-1916. #both authors contributedequally, ** cover article

2009

18.     Steinmetz, N.F., Hong, V., Spoerke, D.E., Lu, P., Breitenkamp, K. Finn, M.G., Manchester, M. (2009) Buckyballs meet viral nanoparticles – Candidates for Biomedicine. J. Am. Chem. Soc., 131, 17093-17095.

17.     Steinmetz, N.F., Shah, S., Barclay, J.E., Rallapalli, S., Lomonossoff, G.P., Evans, D.J. (2009) Virus templated silica nanoparticles. Small 5, 813-816.

16.           Shah S.N., Steinmetz N.F., Aljabali A.A.,Lomonossoff G.P., Evans D.J. (2009)  Environmentallybenign synthesis of virus-templated, monodisperse, iron-platinum nanoparticles. Dalton Trans. 2009 40), 8479-80. 

15. Steinmetz, N.F., Lin T., Lomonossoff, G.P., Johnson, J.E. (2009) Structure-based engineering of an icosahedral virus for nanomedicine and -technology. In Current Topics of Microbiology and Immunology: Viruses and Nanotechnology (Eds. Manchester, M. & Steinmetz, N.F), Wiley-VCH, Weinheim, Germany, pp. 23-58.

14. Eds. Manchester, M. & Steinmetz, N.F., Current Topics of Microbiology andImmunology: Viruses and Nanotechnology, 2009, Wiley-VCH, Weinheim, Germany.

13.     Steinmetz, N.F. and Manchester M. (2009) PEGylated viral nanoparticles for biomedicine: the impact of PEG chain length on VNP cell interactions in vitro and ex vivo. Biomacromolecules 10, 784-792.

12.     Tellechea, E.,Johannsmann, D., Steinmetz, N.F., Richter, R.P., Reviakine, I. (2009) Model-independent analysis of QCM data on colloidal particle adsoption.Langmuir 25(9): 5177-84.

2008

11.     Steinmetz, N.F., Bize, A., Findlay, K.C, Lomonossoff, G.P., Manchester, M., Evans, D.J., Prangishvili, D. (2008) Site-specific and spatially controlled addressability of a new viral nanobuilding block: Sulfolobus islandicus rod-shaped virus 2. Advanced Functional Materials, 18, 2478-3486.

10.     Bingen, P., Wang, G., Steinmetz, N.F., Rodahl, M., Richter, R.P. (2008) Solvation Effects in the Quartz Crystal Microbalance with Dissipation Monitoring Response to Biomolecular Adsorption. A Phenomenological Approach. Analytical Chemistry, 80 (23): 8880-90.

9. Steinmetz, N.F. (2008) Plant viral capsids as programmable nanobuilding blocks. In Tomorrow’s Chemistry Today (Ed. Pignataro B.), Wiley-VCH, Weinheim, Germany, pp. 215-236.

8.     Steinmetz, N.F., Findlay K.C., Noel, T.R., Parker, R., Lomonossoff, G.P., Evans D.J. (2008) Layer-by-layer assembly of viral nanoparticles and polyelectrolytes: The film architecture is different for spheres versus rods. ChemBioChem, 9(10):1662-70.

7.     Steinmetz, N.F., Bock, E., Richter,R.P., Spatz, J.P., Lomonossoff, G.P. and Evans, D.J. (2008) Assembly ofmultilayer arrays of viral nanoparticles via biospecific recognition: a quartzcrystal microbalance with dissipation monitoring study. Biomacromolecules,9(2); 456-462.

2007

6.     Steinmetz, N.F. and Evans, D.J. (2007) Utilisation of plant viruses in bionanotechnology. Org. Biomol. Chem., 5, 2891-2902.

5.     Richter, R.P., Hock, K.K., Burkhartsmeyer, J., Boehm, H., Bingen, P., Wang, G., Steinmetz, N.F., Evans, D.J. and Spatz, J.P. (2007) Membrane-grafted hyaluronan films: a well-defined model system of glycoconjugate cell coats. J. Am. Chem. Soc., 129, 5306-5307.

4.     Steinmetz, N.F., Evans, D.J. andLomonossoff, G.P. (2007) Chemical introduction of reactive thiols into a viralnanoscaffold: a method which avoids virus aggregation. ChemBioChem, 8,1131-1136.

2006

3.     Steinmetz, N.F., Calder, G., Lomonossoff, G.P. and Evans, D.J. (2006) Plant viral capsids as nanobuilding blocks: construction of arrays on solid supports. Langmuir, 22, 10032-10037.

2.     Steinmetz, N.F., Lomonossoff, G.P. and Evans, D.J. (2006) Cowpea mosaic virus for material fabrication: addressable carboxylate groups on a programmable nanoscaffold. Langmuir, 22, 3488-3490.

1.     Steinmetz, N.F., Lomonossoff, G.P. and Evans, D.J. (2006) Decoration of Cowpeamosaic virus with multiple, redox active, organometallic complexes.Small, 2, 530-533.


* denotes Steinmetz Lab trainee


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